About the Anderson Bug Lab

The lab uses both host and microbe-centric approaches to identify the critical points of communication between intestinal bacterial and mammalian epithelial cells. We combine bacterial RNA sequencing with unbiased metabolomic profiling of host cell supernatants in our in vitro and ex vivo reductionist approaches to identify candidate pathways/molecules of interest. From there, we harness the power of bacterial genetics and apply our findings to in vivo models of murine infection, inflammatory disorders, and chemotherapy treatment.

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Experimental toolbox: bacterial genetics, RNA sequencing/qPCR, metatranscriptomics, metabolomics, mammalian cell culture, mammalian genetics, microscopy, flow cytometry, mouse models.